THE INGREDIENTS THAT MAKE IT HAPPEN & THE RESEARCH TO PROVE WE AREN'T MAKING IT UP:

Lemon Balm
Lemon Balm is a perennial herbaceous plant known for its therapeutic benefits and fresh lemon scent. Records showing Lemon Balm's use as a medicinal herb date back over 2000 years. Lemon Balm is historically and contemparily reported to have multiple benefits. However, Lemon Balm is included in CALM due to increasing evidence that Lemon Balm is able to significantly improve calmness as well as reduce cortisol (the primary stress hormone) levels (1). Furthermore, clinical studies have demonstrated that Lemon Balm can successfully be used to significantly improved acute and chronic anxiety and depression  without serious side effects (2). 

Ashwagandha Root
Classical Ayurvedic texts show that Ashwagandha has been used for thousands of years to reduce stress and improve mood and concentration (3). Ashwagandha is considered as a safe and effective adaptogen (a plant used to reduce stress). In fact a recent clinical study concluded that Ashwagandha root extract safely and effectively improves an individual’s resistance towards stress and thereby improves precieved quality of life, due to substantially reduced serum cortisol levels resulting in significant reductions in stress levels (4).  

Holy Basil Leaf
According to the Journal of Ayurveda and Integrative Medicine, Holy Basil Leaf has anti-depressant and anti-anxiety properties comparable to prescription anti-depressant drugs. People using Holy Basil Leaf daily reported less: anxiety, depression and stress. A percentage also felt more sociable and a greater sense of well-being. (5) Evidence is mounting that Holy Basil is able to address not only psychological stress but also physical, chemical and metabolic stress, through a unique combination of actions. Holy Basil has been found to protect organs and tissues against chemical stress from industrial pollutants and heavy metals, as well as oxiditive stress from prolonged physical exertion (6). As such Holy Basil Leaf may provide not only welcomed reductions in stress levels but also other additional benefits in an increasingly fast paced and polluted world. 

Chamomile Flower
The daisy-like plant Chamomile is one of the oldest medicinal herbs known to mankind. Traditionally, Chamomile preparations have been used to treat insomnia and to induce calming effects. Which isn't surprising given that Chamomile is widely regarded as a sleep-inducer. It is thought that Chamomile's sedative effects may be due to the flavonoid, 'apigenin' that binds to benzodiazepine receptors which have sedative and anxiolytic (anxiety reduction) actions(7). There's mounting scientific weight that Chamomile extract can been used as a mild sedative to calm nerves and reduce nightmares, insomnia and other sleep problems (8). 

Zinc
Zinc has for many years been a go to supplement for those looking for immunity support. However, evidence indicates that Zinc may also be involved in the regulation of sleep. This could in part be due to the discovery that orally administered zinc increases the amount and quality of sleep in both animal and human studies (9). Zinc does also plays a vital role in immune response and is critical for sustaining proper immune function. In fact supplementing with Zinc may help reduce the risk of infections (10).  

Magnesium 
Magnesium is a mineral which has recently gained attention as a potential sleep aid. This is perhaps due to research increasingly suggesting that Magnesium helps to activate the parasympathetic nervous system (which is responsible for helping your body feel calm and relaxed). There may be weight to the aforementioned. The results of one randomized controlled trial concluded that "persons with mental and physical stress can benefit from a daily intake of magnesium" (11). 

L-Theanine 
L-theanine, a natural constituent of tea (as well as some mushrooms), is an amino acid able to cross the blood brain barrier and relax the brain without inducing drowsiness (12). A study looking at L-Theanine's effects on stress found that after 4 weeks of L-Theanine administration, stress response symptoms (anxiety, depression and insomnia) decreased. Furthermore, sleep latency (the time taken to go from awake to sleeping) was reduced as were reported sleep disturbances (13). 

Black Pepper Extract 
Black Pepper (Piper Nigrum L.) has long been recognised for its therapeutic potential and traditional use as a potent antioxidant, antimicrobial and gastro-protectant. More specifically, the key alkaloid component of Piper Nigrum, 'piperine' has been shown to assist in cognitive brain functioning, improve gastrointestinal functionality and boost nutrient absorption (14). In fact, piperine is purported to enhance absorption of ingredients by as much as 200%. Although the mechanism of action is not fully understood piperine is thought to increase absorption by stimulating gut amino acid transporters (15). Enhanced absorption means ingredients are used more efficiently and as such greater efficacy.

THE REALLY CLEVER PEOPLE WHO DID THE RESEARCH: 

1) Scholey, A., et al  (2014). Anti-Stress Effects of Lemon Balm-Containing Foods. Nutrients, Volume 6, Pages 4805–4821 

2)  Javid, G., et al (2021). The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis. Phytotherapy Research. Volume 35, Issue 12, Pages 6690-6705.

3) Tandon, N., et al (2020). Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. Journal of ethnopharmacology. Volume 255, 12 June 2020, 112768. 

4) Chandrasekhar, K., et al (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine. Volume 34, Issue 3, Pages 255-262.

5) Cohen, M. (2014) Tulsi - Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine. Volume 5, Issue 4, Pages 251-259. 

6) Manikandan, P., et al (2007). (Holy Basil) ethanolic leaf extract protects against 7,12-dimethylbenz (a) anthracene-induced genotoxicity, oxidative stress, and imbalance in xenobiotic-metabolizing enzymes. Journal of Med Food. Volume 10, Pages 495–502.

7) Avallone, R., et al (1996). Benzodiazepine compounds and GABA in flower heads of matricaria chamomilla. Phytotherapy Res. Volume 10, Pages 177–179.

8) Forster, H. B., et al (1980). Antispasmodic effects of some medicinal plants. Planta Med. Volume 40, Pages 309–319.

9) Cherasse, Y., et al (2017). Dietary zinc acts as a sleep modulator. International journal of molecular sciences. Volume 18, Issue 11, Page 2334.

10) Gammoh, N. Z., et al (2017). Zinc in Infection and Inflammation. Nutrients, Volume 9, Issue 6, Page 624.

11) Wienecke, E., et al (2016). Langzeit-HRV-Analyse zeigt Stressreduktion durch Magnesiumzufuhr [Long-term HRV analysis shows stress reduction by magnesium intake]. MMW Fortschritte der Medizin, Volume 158, Suppl 6, Pages 12–16. 
12) Nobre, A. C., et al (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific journal of clinical nutrition,  Volume 17, Suppl 1, Pages 167–168.

13) Hidese, S., et al (2019)  Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. Volume 11, Issue 10, Page 2362. 

14. Butt, M. S., et al (2013). Black pepper and health claims: a comprehensive treatise. Critical reviews in food science and nutrition, Volume 53, Issue 9, Pages 875–886. 

15. Kesarwani, K.,et al (2013). Bioavailability enhancers of herbal origin: an overview. Asian Pacific journal of tropical biomedicine, Volume 3, Issue 4, Pages 253–266. 

FREQUENTLY ASKED QUESTIONS

Can Women Use CALM?
YES, absolutely! The ingredients found in CALM are safe for men and women to use, as long as you follow the suggested use found on the bottle. However, we'd recommend that you seek professional advice if you are pregnant, planning pregnancy or are breast feeding.

Is CALM Vegan?
YES, we love animals. Like all Saint Supplements products CALM is 100% Vegan. We only ever make vegan products, if we can't make a product vegan, we won't make it at all. You'll be pleased to know that none of our supplements are ever tested on animals either. 

Will CALM Make Me Tired The Next Morning?
No, not usually. CALM's blend of soothing plant extracts, are designed to work in harmony with your body. Most people find that they wake up refreshed and relaxed following a restful night of sleep.

Can I Use CALM When Fasting?
Yes, you can. The ingredients used in CALM are effective with or without food. 

Should I Use CALM Every Day/Night? 
We believe a balanced approach is the best way to approach things in life. However, we also appreciate that stress levels can get out of balance. How you choose to use CALM will depend on your circumstances. We suggest seeking professional advice prior to using CALM for extended periods.

Is CALM Quality Tested? 
YES, to strict standards. During manufacturing our supplements go through analytical testing to ensure that the ingredients found in our supplements conform with strict EU Regulations. More importantly, testing ensures our supplements are free from harmful contaminants such as: bacteria, pesticides and heavy metals. You can find out more about our supplements here.

Do You Have Any Samples of CALM?
YES, of course. We believe in our products and encourage our customers to try before they buy. We also want to spread the love to your friends and family. That's why we always include free samples with any product purchase (there's nothing worse than your friends trying to cadge your supps). However, we do ask that you cover the postage cost for your samples (if you're not already buying a product). The great news is, we'll include a discount code with the samples to ensure if you do order, you'll get 10% OFF and free delivery. That should cover your costs and ours. You can order your free samples here.  

Nutritional Information
Serving Size: 1 Capsule
Servings Per Container: 120 Servings
Amount Per Capsule:
Vitamin B6 - 1.5mg 
Magnesium - 56mg 
Zinc - 5mg 
L-Theanine - 100mg 
Lemon Balm 4:1 Extract - 25mg
Ashwagandha Root 10:1 Extract - 15mg
Holy Basil Leaf 10:1 Extract - 12.5mg
Hops 7:1 Extract - 9mg
Chamomile 12:1 Extract - 6.25mg
Black Pepper 30:1 Extract (95% Piperine) - 1.25mg

Ingredients: Vegan Diluents (Microcrystalline Cellulose, Dicalcium Phosphate DC), Vegan Capsule (HydroxyPropylMethylCellulose), L-Theanine, Magnesium Oxide DC, Lemon Balm 4:1 Extract (Melissa Officinalis), Ashwagandha Root 10:1 Extract (5% Withanolides) (Withania Somnifera) Vegan Anti-Caking Agents (Magnesium Stearate, Silicone Dioxide), Holy Basil Leaf 10:1 Extract (Ocimum Sanctum), Hops 7:1 Extract (Humulus Lupulus L), Zinc Oxide, Chamomile Flower 12:1 Extract (Matricaria Recutita L), Vitamin B6 (Pyridoxine Hydrochloride), Black Pepper 30:1 Extract (95% Piperine) (Piper Nigrum).  
 

Suggested Use: Adults take 1-4 capsules with water. 1 to 2 capsules may help to contribute to a more relaxed state during the day. Alternatively, up to 4 capsules can be taken approximately 45 minutes before bed to help contribute to normal and restful sleep. Recommended: to assess tolerance, take 1 capsule with water mid-afternoon.